Fluorouracil
CLINICAL USE
Antineoplastic agent
DOSE IN NORMAL RENAL FUNCTION
IV infusion
: 15 mg/kg/day to a total dose of 12–15 gIV bolus: 12 mg/kg/day for 3 days, then 6 mg/kg on alternate days or 15 mg/kg once a weekMaintenance: 5–15 mg/kg once a week Intra-arterial infusion: 5–7.5 mg/kg by continuous 24-hour infusionOral: 15 mg/kg weekly; maximum 1 g in a dayOr consult relevant local chemotherapy protocol
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
Consult relevant local protocol
Route
IV infusion
intermittent or continuous, IV injection, intra-arterial, oral, topical
Rate of Administration
30–60 minutes, 4 hours or as a continuous infusion over 24 hours or consult relevant local protocol
Comments
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OTHER INFORMATION
Use ideal body weight in patients showing obesity, ascites, and oedemaRoche recommends decreasing the initial dose by one-third to one-half in patients with impaired hepatic or renal functionDistributed throughout the body water, activated in target cells, most of dose (80%) is metabolised by the liver, 60–80% is excreted as respiratory CO2 and 2–3% by the biliary systemFollowing a single IV dose, approximately 15% is excreted unchanged in the urine.