Fexofenadine hydrochloride

CLINICAL USE


Antihistamine:Symptomatic relief of rhinitis and urticaria

DOSE IN NORMAL RENAL FUNCTION

120–180 mg daily depending on condition

PHARMACOKINETICS

  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :538.1
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :60–70
  • %Excreted unchanged in urine &nbsp &nbsp : 10

  • Volume of distribution (L/kg) &nbsp &nbsp &nbsp :5–6

  • half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :11–15/19–25

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function. Use with care
  • 10 to 20 &nbsp &nbsp : Initial dose 60 mg once or twice daily. ‘See Other Information’
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Initial dose 60 mg once daily. See ‘Other Information’

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely dialysability. Dose as in GFR <10 mL/min

  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL/min
  • HDF/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR 10 to 20 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsAluminium/magnesium containing antacids: reduced absorption – avoid for 2 hours

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

    Comments

    Take before food

    OTHER INFORMATION

    Less than 1.5% of a dose is metabolised via the CP450 3A4 systemLarger doses may be used in patients with renal impairment, but increase carefully as can result in increased sedation
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