Felodipine

CLINICAL USE

Calcium-channel blocker:Hypertension Angina

DOSE IN NORMAL RENAL FUNCTION

Hypertension: 5–20 mg once dailyAngina: 5–10 mg daily

PHARMACOKINETICS

  • Molecular weight                           :384.3
  • %Protein binding                           :99
  • %Excreted unchanged in urine     : <0.5
  • Volume of distribution (L/kg)       :10
  • half-life – normal/ESRD (hrs)      :24/Unchanged

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Not dialysed. Dose as in normal renal function
  • CAV/VVHD      :Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Anaesthetics: enhanced hypotensive effect
  • Antibacterials: metabolism possibly inhibited by erythromycin
  • Anti-epileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone
  • Antifungals: metabolism inhibited by itraconazole and ketoconazoleAntihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of post-synaptic alpha-blockers
  • Antivirals: concentration possibly increased by ritonavir
  • Grapefruit juice: concentration increased – avoid concomitant use
  • Tacrolimus: possibly increased tacrolimus concentrationTheophylline: possibly increased theophylline concentration

    ADMINISTRATION

    Reconstition

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    Route

    Oral

    Rate of Administration

    –

    Comments

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