20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function
<10           : Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Dialysed. Dose as in normal renal function
HD                     :Dialysed. Dose as in normal renal function
HDF/high flux   :Dialysed. Dose as in normal renal function
CAV/VVHD      :Dialysed. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Antibacterials: concentration increased by isoniazid
Antidepressants: lower convulsive threshold
Anti-epileptics: concentration possibly reduced by carbamazepine, phenytoin and primidone; concentration of phenytoin possibly increased; concentration increased by valproate
Antimalarials: possibly increased risk of convulsions with chloroquine and hydroxychloroquine; anticonvulsant effect antagonised by mefloquine