30–50 Dose as in normal renal function10–30 Use 50–100% of dose
<10           : Use 50% of dose, or 1 g 3 times a week. See ‘Other Information’
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Dialysed. Dose as in GFR
<10           : mL/min
HD                     :Dialysed. Dose as in GFR
<10           : mL/min
HDF/high flux   :Dialysed. Dose as in GFR
<10           : mL/min
CAV/VVHD      :Dialysed. Dose as in GFR=10–30 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
None known
ADMINISTRATION
Reconstition
10 mL water for injection or sodium chloride 0.9%
Route
IV, (IM – not licensed)
Rate of Administration
IV Infusion: 30 minutes
Comments
Dilute in sodium chloride 0.9% only Incompatible with glucose Dilute solutions are stable for 6 hours at room temperature or 24 hours in a refrigerator. Use within 4 hours of removal from refrigerator
OTHER INFORMATION
Approximately 30% of dose is dialysed after a 4 hour haemodialysis sessionAnother on-line reference source says that 100% of the dose can be used in people with a GFR of 10–50 mL/minAnecdotally ertapenem has been used at a dose of 1 g 3 times a weekGive at least 6 hours before haemodialysis session if unable to give post dialysis.