doxycycline.txt doxycycline CLINICAL USE Antibacterial agentProphylaxis/treatment of malaria DOSE IN NORMAL RENAL FUNCTION 200 mg on day 1, then 100 mg daily; severe infections 200 mg dailyLate latent syphilis: 200 mg twice daily Malaria: treatment: 200 mg once daily; prophylaxis: 100 mg daily PHARMACOKINETICS Molecular weight                           :462.4 %Protein binding                           :>90 %Excreted unchanged in urine     : 33–45 Volume of distribution (L/kg)       :0.7 half-life – normal/ESRD (hrs)      :18/Unchanged DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in normal renal function HD                     :Not dialysed. Dose as in normal renal function HDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Not dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione Ciclosporin: possibly increases plasma- ciclosporin concentration Oestrogens: possibly reduced contraceptive effects of oestrogens (risk probably small) Retinoids: possible increased risk of benign intracranial hypertension – avoid concomitant use ADMINISTRATION Reconstition– Route Oral Rate of Administration –CommentsDo not take iron preparations, indigestion remedies or phosphate binders at the same time of day as doxycycline. Tags: post-by-auto-php Continue Reading Previous Previous post: Zotepine.txtNext Next post: hydrocortisone acetate.txt Related News sotalol hydrochloride.txt tazocin.txt