doxapram hydrochloride.txt doxapram hydrochloride CLINICAL USE Postoperative respiratory depression Acute respiratory failure DOSE IN NORMAL RENAL FUNCTION Postoperative respiratory depression: IV injection 1–1.5 mg/kg repeated at hourly intervals, or IV infusion 2–3 mg/minute, adjusted according to response. Acute respiratory failure: 1.5–4 mg/minute as an IV infusion , adjusted according to response PHARMACOKINETICS Molecular weight                           :433 %Protein binding                           :No data %Excreted unchanged in urine     : <5 Volume of distribution (L/kg)       :0.58–2.74 half-life – normal/ESRD (hrs)      :2.4–4.1/– DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unknown dialysability. Dose as in normal renal function HD                     :Unknown dialysability. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs None known ADMINISTRATION Reconstition– Route IV bolus, IV infusion Rate of Administration IV injection: over at least 30 seconds IV infusion as indication CommentsDoxapram has a narrow margin of safety; the minimum effective dosage should be used and maximum recommended dosages should not be exceeded OTHER INFORMATION Unlike naloxone, doxapram does not reverse the other effects of opioid analgesics Tags: post-by-auto-php Continue Reading Previous Previous post: Zotepine.txtNext Next post: hydrocortisone acetate.txt Related News sotalol hydrochloride.txt tazocin.txt