doxapram hydrochloride

CLINICAL USE

Postoperative respiratory depression Acute respiratory failure

DOSE IN NORMAL RENAL FUNCTION

Postoperative respiratory depression: IV injection 1–1.5 mg/kg repeated at hourly intervals, or

IV infusion

2–3 mg/minute, adjusted according to response. Acute respiratory failure: 1.5–4 mg/minute as an

IV infusion

, adjusted according to response

PHARMACOKINETICS

  • Molecular weight                           :433
  • %Protein binding                           :No data
  • %Excreted unchanged in urine     : <5
  • Volume of distribution (L/kg)       :0.58–2.74
  • half-life – normal/ESRD (hrs)      :2.4–4.1/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Unknown dialysability. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    –

    Route

    IV bolus,

    IV infusion

    Rate of Administration

    IV injection: over at least 30 seconds

    IV infusion

    as indication

    Comments

    Doxapram has a narrow margin of safety; the minimum effective dosage should be used and maximum recommended dosages should not be exceeded

    OTHER INFORMATION

    Unlike naloxone, doxapram does not reverse the other effects of opioid analgesics

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