20 to 50     : Dose as in normal renal function and adjust to response
10 to 20     : Dose as in normal renal function and adjust to response
<10           : Dose as in normal renal function and adjust to response
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in normal renal function
HD                     :Unknown dialysability. Dose as in normal renal function
HDF/high flux   :Unknown dialysability. Dose as in normal renal function
CAV/VVHD      :Unknown dialysability. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide
Beta-blockers: risk of severe hypertension
Sympathomimetics: effects of adrenaline and noradrenaline possibly enhanced
ADMINISTRATION
Reconstition
–
Route
By intravenous infusion into a central or large peripheral vein
Rate of Administration
See dosage instructions
Comments
IV infusion
of 400 or 800 micrograms/mL in glucose 5% or sodium chloride 0.9%Peripheral administration: concentration of infusion solution must not exceed 1 mg/mL
Central administration: concentration not >4 mg/mLRate of administration and duration of therapy should be adjusted according to the patient’s response as determined by heart rate and rhythm, blood pressure, urine flow and measurement of cardiac output