dopexamine hydrochloride
CLINICAL USE
Inotropic support in exacerbations of heart failure and heart failure associated with cardiac surgery
DOSE IN NORMAL RENAL FUNCTION
IV infusion
: 0.5 –1 mcg/kg/minute and then in increments (0.5–1 micrograms/kg/minute) up to 6 micrograms/kg/minute at not less than 15 minute intervals
PHARMACOKINETICS
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
ADMINISTRATION
Reconstition
–
Route
By intravenous infusion into a central or large peripheral vein
Rate of Administration
See dosage instructions
Comments
IV infusion
of 400 or 800 micrograms/mL in glucose 5% or sodium chloride 0.9%Peripheral administration: concentration of infusion solution must not exceed 1 mg/mL
OTHER INFORMATION
Avoid abrupt withdrawal