Darunavir

CLINICAL USE

Protease inhibitor:Treatment of HIV infection with 100 mg of ritonavir, in combination with other antiretroviral medication

DOSE IN NORMAL RENAL FUNCTION

600 mg twice daily

PHARMACOKINETICS

Molecular weight :593.7 (as ethanolate)

%Protein binding :95

%Excreted unchanged in urine : 7.7

Volume of distribution (L/kg) :29.1–147.1 litres (81.1–180.9 litres with ritonavir)

half-life – normal/ESRD (hrs) :15 (with ritonavir)/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unlikely to be dialysed. Dose as in normal renal function

HD :Unlikely to be dialysed. Dose as in normal renal function

HDF/high flux :Unlikely to be dialysed. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAntibacterials: rifabutin concentration increased – reduce dose of rifabutin; darunavir concentration reduced by rifampicin – avoid concomitant useAntidepressants: possibly reduced concentration of paroxetine and sertraline; darunavir concentration reduced by St John’s wort – avoid concomitant use

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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