Chlorphenamine maleate.txt Chlorphenamine maleate CLINICAL USE Antihistamine: Relief of allergy, pruritus Treatment/prophylaxis of anaphylaxis DOSE IN NORMAL RENAL FUNCTION Oral: 4 mg 4–6 times a day (maximum 24 mg/day)IV/IM/SC: 10–20mg (maximum 40 mg/day) PHARMACOKINETICS Molecular weight                           :390.9 %Protein binding                           :Approx 70 %Excreted unchanged in urine     : Approx 22 Volume of distribution (L/kg)       :3 half-life – normal/ESRD (hrs)      :12–43/– DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function. See ‘Other Information’ DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in normal renal function HD                     :Dialysed. Dose as in normal renal functionHDF/high flux   :Dialysed. Dose as in normal renal functionCAV/VVHD      :Dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Inhibits phenytoin metabolism and can lead to phenytoin toxicity ADMINISTRATION Reconstition– Route Oral, IV Rate of Administration Bolus over 1 minute Comments Injection reported to cause stinging or burning sensation at site of injection OTHER INFORMATION Increased cerebral sensitivity in patients with renal impairment Tags: post-by-auto-php Continue Reading Previous Previous post: CUSHINGS SYNDROME .txtNext Next post: Cinacalcet.txt Related News sotalol hydrochloride.txt tazocin.txt