Chlorphenamine maleate

CLINICAL USE

Antihistamine:

Relief of allergy, pruritus

Treatment/prophylaxis of anaphylaxis

DOSE IN NORMAL RENAL FUNCTION

Oral: 4 mg 4–6 times a day (maximum 24 mg/day)IV/IM/SC: 10–20mg (maximum 40 mg/day)

PHARMACOKINETICS

Molecular weight :390.9

%Protein binding :Approx 70

%Excreted unchanged in urine : Approx 22

Volume of distribution (L/kg) :3

half-life – normal/ESRD (hrs) :12–43/–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function. See ‘Other Information’

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Dialysed. Dose as in normal renal function

HDF/high flux :Dialysed. Dose as in normal renal function

CAV/VVHD :Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Inhibits phenytoin metabolism and can lead to phenytoin toxicity

ADMINISTRATION

Reconstition

–

Route

Oral, IV Rate of Administration Bolus over 1 minute

Comments

Injection reported to cause stinging or burning sensation at site of injection

OTHER INFORMATION

Increased cerebral sensitivity in patients with renal impairment

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