Cetirizine hydrochloride.txt Cetirizine hydrochloride CLINICAL USE Antihistamine: Symptomatic relief of allergy such as hay fever, urticaria DOSE IN NORMAL RENAL FUNCTION 10 mg daily or 5 mg twice daily PHARMACOKINETICS Molecular weight                           :461.8 %Protein binding                           :93 %Excreted unchanged in urine     : 50–60 Volume of distribution (L/kg)       :0.45 half-life – normal/ESRD (hrs)      :8–10/20 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : 5–10 mg daily DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unlikely dialysability. Dose as in GFR <10 mL/min HD                     :Not dialysed. Dose as in GFR <10 mL/min HDF/high flux   :Not dialysed. Dose as in GFR <10 mL/min CAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs None known ADMINISTRATION Reconstition– Route Oral Rate of Administration –CommentsAvailable as tablets and solution OTHER INFORMATION Manufacturers recommend halving dose in renal impairment Dose may be titrated up but may result in increased sedation Less than 10% of a dose is removed by haemodialysis Tags: post-by-auto-php Continue Reading Previous Previous post: CUSHINGS SYNDROME .txtNext Next post: Cinacalcet.txt Related News sotalol hydrochloride.txt tazocin.txt