Cefradine

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 250–500 mg every 6 hours (or 500 mg – 1 g every 12 hours)Severe infections: 1 g every 6 hoursInjection: 0.5–2 g every 6 hoursSurgical prophylaxis: 1–2 g at induction

PHARMACOKINETICS

  • Molecular weight                           :349.4
  • %Protein binding                           :8–12
  • %Excreted unchanged in urine     : >90
  • Volume of distribution (L/kg)       :0.25–0.46
  • half-life – normal/ESRD (hrs)      :1/6–15

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : 250–500 mg every 6 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :dialysed. Dose as in GFR
  • <10           : mL/min
  • HD                     :Dialysed. Dose as in GFR
  • <10           : mL/min
  • HDF/high flux   :Dialysed. Dose as in GFR
  • <10           : mL/min
  • CAV/VVHD      :Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced

    ADMINISTRATION

    Reconstition

    IM: 2 mL of water for injection or sodium chloride 0.9% to each 500 mg

  • IV bolus: 5 mL of water for injection, sodium chloride 0.9% or glucose 5% to each 500 mg
  • IV infusions: 10 mL of suitable diluent to 1 g vial then add to infusion solution

    Route

    Oral, IM, IV

    Rate of Administration

    IV bolus: over 3–5 minutes

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