Cefpodoxime

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

100–200 mg every 12 hours

PHARMACOKINETICS

Molecular weight :557.6 (as proxetil)

%Protein binding :20–40

%Excreted unchanged in urine : 80

Volume of distribution (L/kg) :0.6–1.2

half-life – normal/ESRD (hrs) :2.4/26

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : 100–200 mg every 24 hours

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Dialysed. Dose as in GFR

<10 : mL/min

HDF/high flux :Dialysed. Dose as in GFR

<10 : mL/min

CAV/VVHD :Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

Take with food Antacids and H 2-blockers should be taken 2–3 hours after administration of cefpodoxime.

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