Cefotaxime.txt Cefotaxime CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION Mild infection: 1 g every 12 hours Moderate infection: 1 g every 8 hours Severe infection: 2 g every 6 hours Life-threatening infection: up to 12 g daily in 3–4 divided doses PHARMACOKINETICS Molecular weight                           :477.4 (as sodium salt) %Protein binding                           :40 %Excreted unchanged in urine     : 40–60 Volume of distribution (L/kg)       :0.15–0.55 half-life – normal/ESRD (hrs)      :0.9–1.14/2.5 (10 hours for the metabolite) DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : 1 g every 8–12 hours DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in GFR <10 mL/min HD                     :Dialysed. Dose as in GFR <10           : mL/min HDF/high flux   :Dialysed. Dose as in GFR <10           : mL/min CAV/VVHD      :Dialysed. 1–2 g every 12 hours CVVhd/HDFDialysed. 2 g every 12 hours1 IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Anticoagulants: effects of coumarins may be enhanced ADMINISTRATION ReconstitionIV Bolus/IM: 4 mL water for injection to 1 gIV Infusion: 1 g in 50 mL sodium chloride 0.9% Route IV, IM Rate of Administration Bolus over 3–4 minutes; infusion over 20–60 minutesComments– OTHER INFORMATION 1 g contains 2.09 mmol sodium Reduce dose further if concurrent hepatic and renal failure Tags: post-by-auto-php Continue Reading Previous Previous post: CUSHINGS SYNDROME .txtNext Next post: Cinacalcet.txt Related News sotalol hydrochloride.txt tazocin.txt