Cefadroxil

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

500 mg – 1 g every 12–24 hours

PHARMACOKINETICS

  • Molecular weight                           :381.4
  • %Protein binding                           :20
  • %Excreted unchanged in urine     : >90
  • Volume of distribution (L/kg)       :0.31
  • half-life – normal/ESRD (hrs)      :1.3–2/22

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : 500 mg – 1 g every 24 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in GFR <10 mL/min
  • HD                     :Dialysed. Dose as in GFR
  • <10           : mL/min
  • HDF/high flux   :Dialysed. Dose as in GFR
  • <10           : mL/min
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    –

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