Calcium resonium

CLINICAL USE

Hyperkalaemia (not for emergency treatment)

DOSE IN NORMAL RENAL FUNCTION

Oral: 15 g 3–4 times daily in water

  • PR: 30 g in methylcellulose solution retained for 9 hours

    PHARMACOKINETICS

  • Molecular weight                           :–
  • %Protein binding                           :–
  • %Excreted unchanged in urine     : 0
  • Volume of distribution (L/kg)       :–
  • half-life – normal/ESRD (hrs)      :–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function. Titrate to response
  • 10 to 20     : Dose as in normal renal function. Titrate to response
  • <10           : Dose as in normal renal function. Titrate to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Not dialysed. Dose as in normal renal function
  • CAV/VVHD      :Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • None known

    ADMINISTRATION

    Reconstition

    PR: Mix with methylcellulose solution 2% Oral: Mix with a little water, sweetened if preferred

    Route

    Oral or PR

    Rate of Administration

    Comments

    OTHER INFORMATION

  • Ensure a regular laxative is prescribed – can mix Calcium Resonium powder with lactulose to be taken orally
  • Some units mix dose with a little water and give PR 4 times/day. Not retained for so long, but still effective
  • Calcium Resonium is not absorbed
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