Calcium gluconate

CLINICAL USE

Hypocalcaemia

DOSE IN NORMAL RENAL FUNCTION

Depending on indication

  • Acute hypocalcaemia:
  • 10 to 20     : mL calcium gluconate 10% (2.25–4.5 mmol calcium) slow
  • IV injection over 3–10 minutes
  • Oral: Dose varies depending on requirements

    PHARMACOKINETICS

  • Molecular weight                           :448.4
  • %Protein binding                           :–
  • %Excreted unchanged in urine     : –
  • Volume of distribution (L/kg)       :–
  • half-life – normal/ESRD (hrs)      :–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function. Titrate to response
  • 10 to 20     : Dose as in normal renal function. Titrate to response
  • <10           : Dose as in normal renal function. Titrate to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Dialysed. Dose as in normal renal function
  • HD                     :Dialysed. Dose as in normal renal function
  • HDF/high flux   :Dialysed. Dose as in normal renal function
  • CAV/VVHD      :Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Can impair absorption of some drugs, e.g. iron, ciprofloxacin

    ADMINISTRATION

    Reconstition

    Route

    Oral, IV, IM

    Rate of Administration

    IV: slow 3–4 minutes for each 10 mL (2.25 mmol calcium); not greater than 20 mmol/hour for continuous infusions

    Comments

    IV: Can be used undiluted for continuous and intermittent infusions

    OTHER INFORMATION

  • Check patient’s magnesium levels
  • Monitor calcium and PO 4 serum levels
  • Calcium-Sandoz 400: 10 mmol calcium per tablet
  • Calcium-Sandoz 1000: 25 mmol calcium per tablet
  • Calcium levels cannot be corrected until magnesium levels are normal
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