Calcium carbonate

CLINICAL USE

Phosphate binding agent

Calcium supplement

DOSE IN NORMAL RENAL FUNCTION

Dose adjusted according to serum phosphate and calcium levels

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :100.1

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :40

%Excreted unchanged in urine &nbsp &nbsp : –

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :–

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function. Titrate to response

10 to 20 &nbsp &nbsp : Dose as in normal renal function. Titrate to response

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function. Titrate to response

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in normal renal function

HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Can impair absorption of some drugs, e.g. iron, ciprofloxacin

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

Comments

Take with or immediately before meals

OTHER INFORMATION

Monitor for hypercalcaemia particularly if patient is also taking alfacalcidol

Calcichew contains 1250 mg calcium carbonate (500 mg elemental calcium)Calcium 500 contains 1250 mg calcium carbonate (500 mg elemental calcium)

Cacit contains 1250 mg calcium carbonate (500 mg elemental calcium).

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