Calcium carbonate

CLINICAL USE

  • Phosphate binding agent
  • Calcium supplement

    DOSE IN NORMAL RENAL FUNCTION

    Dose adjusted according to serum phosphate and calcium levels

    PHARMACOKINETICS

  • Molecular weight                           :100.1
  • %Protein binding                           :40
  • %Excreted unchanged in urine     : –
  • Volume of distribution (L/kg)       :–
  • half-life – normal/ESRD (hrs)      :–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function. Titrate to response
  • 10 to 20     : Dose as in normal renal function. Titrate to response
  • <10           : Dose as in normal renal function. Titrate to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Unknown dialysability. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs

  • Can impair absorption of some drugs, e.g. iron, ciprofloxacin

    ADMINISTRATION

    Reconstition

    –

    Route

    Oral

    Rate of Administration

    Comments

    Take with or immediately before meals

    OTHER INFORMATION

  • Monitor for hypercalcaemia particularly if patient is also taking alfacalcidol
  • Calcichew contains 1250 mg calcium carbonate (500 mg elemental calcium)Calcium 500 contains 1250 mg calcium carbonate (500 mg elemental calcium)
  • Cacit contains 1250 mg calcium carbonate (500 mg elemental calcium).
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