Bromocriptine

CLINICAL USE

Parkinsonism (but not drug-induced extrapyramidal symptoms)

Endocrine disorders

DOSE IN NORMAL RENAL FUNCTION

Parkinson’s disease: Week 1: 1–1.25 mg at night —Week 2: 2–2.5 mg at night —Week 3: 2.5 mg twice daily —Week 4: 2.5 mg, 3 times daily —then increasing by 2.5 mg every —3–14 days according to response – usual range 10–40 mg daily

Hypogonadism/galactorrhoea, infertility: 1–1.25 mg at night, increased gradually; usual dose 7.5 mg daily in divided doses (maximum 30 mg daily); infertility without hyperprolactinaemia: 2.5 mg twice daily

Cyclical benign breast disease and cyclical menstrual disorders: 1–1.25 mg at night increased gradually; usual dose 2.5 mg twice daily

Acromegaly: 1–1.25 mg at night increased gradually to 5 mg every 6 hours

Prolactinoma: 1–1.25 mg at night increased gradually to 5 mg every 6 hours (maximum 30 mg daily)

PHARMACOKINETICS

Molecular weight :750.7 (as mesilate)

%Protein binding :90–96

%Excreted unchanged in urine : 2.5–5.5

Volume of distribution (L/kg) :1–3

half-life – normal/ESRD (hrs) :8–20/–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsIncreased risk of toxicity with bromocriptine and isometheptene or phenylpropanolamine

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

Take with food

OTHER INFORMATION

Hypotensive reactions may occur during the first few days of treatment. Tolerance may be reduced by alcoholDigital vasospasm can occur

Concomitant administration of macrolide antibiotics may elevate bromocriptine levels.

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