Azithromycin.txt Azithromycin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION Genital chlamydial infections: 1 g as single dose All other indications: 500 mg daily for 3 days Typhoid (unlicensed): 500 mg daily for 7 days PHARMACOKINETICS Molecular weight                           :785 %Protein binding                           :12–52 %Excreted unchanged in urine     : 6–12 Volume of distribution (L/kg)       :31.1 half-life – normal/ESRD (hrs)      :48–96/– DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in normal renal function HD                     :Unknown dialysability. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Antibacterials: possibly increased rifabutin concentration (increased risk of uveitis) – reduce dose of rifabutin) Anticoagulants: effect of coumarins may be enhanced Antidepressants: the manufacturer of reboxetine advises to avoid concomitant use Antihistamines: may inhibit the metabolism of mizolastine (risk of hazardous arrhythmias) – avoid concomitant use Antimalarials: avoid concomitant use with artemether/lumefantrine Antipsychotics: possibly increased quetiapine concentration – reduce quetiapine dose; possibly increased risk of ventricular arrhythmias with sertindole – avoid concomitant use Antivirals: concentration possibly increased by ritonavir Ciclosporin: may inhibit the metabolism of ciclosporin (increased plasma ciclosporin levels) Ergot alkaloids: increased risk of ergotism – avoid concomitant use Theophylline: possibly increased theophylline concentration ADMINISTRATION ReconstitionPowder for oral suspension to be reconstituted with water (200 mg/5 mL strength) Route Oral Rate of Administration –CommentsAdminister as a once daily dose 1 hour before food or 2 hours after food. Tags: post-by-auto-php Continue Reading Previous Previous post: Atovaquone.txtNext Next post: Bortezomib.txt Related News sotalol hydrochloride.txt tazocin.txt