Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone
Antidepressants: enhanced hypotensive effect with MAOIs
Antihypertensives: enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin
Antimalarials: increased risk of bradycardia with mefloquine
Antipsychotics enhanced hypotensive effect with phenothiazines
Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil
Diuretics: enhanced hypotensive effect Moxisylyte: possible severe postural hypotension
Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine
Tropisetron: increased risk of ventricular arrhythmias – use with caution
ADMINISTRATION
Reconstition
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Route
Oral, IV
Rate of Administration
Infusion: 20 minutes IV injection: 1 mg/minute
Comments
Dilute with glucose 5% or sodium chloride 0.9%
OTHER INFORMATION
C
SM advise that beta-blockers are contraindicated in patients with asthma or history of obstructive airway disease