Ascorbic acid

CLINICAL USE

Acidification of urine

Vitamin C deficiency

DOSE IN NORMAL RENAL FUNCTION

Up to 4 g daily in divided doses

Prophylaxis: 25–75 mg daily

Therapeutic: 250 mg daily in divided doses

IV: 0.5–1 g daily

Preventative therapy: 200–500 mg daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
176.1

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
25

%Excreted unchanged in urine &nbsp &nbsp :
Minimal1

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :
No data

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :
3–4/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp :
Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
Dialysed. Dose as in normal renal
function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
Dialysed. Dose as in normal renal
function

HDF/high flux &nbsp :
Dialysed. Dose as in normal renal
function

CAV/VVHD &nbsp &nbsp &nbsp:
Dialysed. Dose as in normal renal
function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs
None known

ADMINISTRATION

Reconstition

–

Route

Oral, IV

Rate of Administration

–

Comments

–

OTHER INFORMATION

No scientific evidence from clinical trial of

efficacy in reducing UTI via acidification
of urine

In CKD 5 on dialysis, requirements are

usually about 75–90 mg per day. (Kalanter-
Zadeh K, Kopple JD. Trace elements and
vitamins in maintenance dialysis patients.

Try to use lower doses in CKD 5 patients

due to risk of oxalate formation

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