Artemether with lumefantrine

CLINICAL USE

Treatment of malaria

DOSE IN NORMAL RENAL FUNCTION

>35 kg: 6 doses of 4 tablets, i.e. 24 tablets
given over 60 hours
Give 4 tablets at 0, 8, 24, 36, 48 and 60 hours

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
Artemether: 298.4;
lumefantrine: 528.9

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
Artemether: 95.4;
lumefantrine: 99.9

%Excreted unchanged in urine &nbsp &nbsp :
No data

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :
Artemether: 5.4–8.6;
lumefantrine: 3.8

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :
Artemether 0.8–7;
lumefantrine: 48–72
(4–6 days in people
with falciparum
malaria)

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp :
Dose as in normal renal function.
Use with caution

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
Unknown dialysability. Dose as in
GFR <10 mL/min

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
Unknown dialysability. Dose as in
GFR <10 mL/min

HDF/high flux &nbsp :
Unknown dialysability. Dose as in
GFR <10 mL/min

CAV/VVHD &nbsp &nbsp &nbsp:
Unknown dialysability. Dose as in
normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anti-arrhythmics: avoid concomitant use

with amiodarone, disopyramide, flecainide
and procainamide – risk of ventricular
arrhythmias
Antibacterials: avoid concomitant use with

macrolides and quinolones.

Antidepressants: avoid concomitant use

Antifungals: avoid concomitant use with

imidazoles and triazoles.
Antimalarials: increased risk of ventricular

arrhythmias with quinine – avoid
concomitant use.

Antipsychotics: avoid concomitant use

Antivirals: avoid concomitant use with

amprenavir, atazanavir, indinavir, lopinavir,
nelfinavir, ritonavir and saquinavir;
possibly increased risk of ventricular
arrhythmias with tipranavir – avoid
concomitant use
Beta-blockers: avoid concomitant use with

metoprolol and sotalol

Grapefruit juice: may increase

bioavailability and inhibit metabolism –
avoid concomitant use
Ulcer-healing drugs: avoid concomitant

use with cimetidine

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

Take with food to increase absorption

If patient vomits within 1 hour of taking

the tablet the dose should be repeated

OTHER INFORMATION

In renal impairment monitor ECG and

potassium levels

Undergoes extensive metabolism by the

liver

Tags: post-by-auto-php