Anidulafungin

CLINICAL USE

Antifungal agent:
Invasive candidiasis

DOSE IN NORMAL RENAL FUNCTION

200 mg loading dose then 100 mg daily
Oesophageal candidiasis: 100 mg loading
dose then 50 mg daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
1140.2

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
>99

%Excreted unchanged in urine &nbsp &nbsp :
<1

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :
30–50 litres

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :
40–50/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :
Unlikely to be dialysed. Dose as in
normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:
Unlikely to be dialysed. Dose as in
normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs
None known

ADMINISTRATION

Reconstition

With diluent provided

Route

IV infusion

Rate of Administration

1.1 mg/minute (3 mL/minute)

Comments

Can be further diluted in sodium chloride

0.9% or glucose 5%.
Add 100 mg to 250 mL or 200 mg to

500 mL of fluid

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