Amoxicillin

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

250 mg – 1 g every 8 hours (maximum 6 g per
day, up to 12 g in endocarditis)

PHARMACOKINETICS

Molecular weight :
365.4

%Protein binding :
20

%Excreted unchanged in urine :
60

Volume of distribution (L/kg) :
0.3

half-life – normal/ESRD (hrs) :
1–1.5/7–20

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 :
250 mg – 1 g every 8 hours
(Maximum 6 g per day in
endocarditis)

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :
Not dialysed. Dose as in
GFR <10 mL/min

HD :
Dialysed. Dose as in GFR

<10 : mL/
min

HDF/high flux :
Dialysed. Dose as in GFR

<10 : mL/
min

CAV/VVHD :
Dialysed. Dose as in normal renal
function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Amoxicillin can reduce the excretion ofmethotrexate (increased risk of toxicity)

ADMINISTRATION

Reconstition

IV: Dissolve each 250 mg in 5 mL water forinjection

IV Infusion: Dilute in 100 mL glucose 5%or sodium chloride 0.9%

IM: Dissolve 250 mg in 1.5 mL water forinjection; 500 mg in 2.5 mL water for
injection; 1 g in 2.5 mL water for injection
or 1% sterile lidocaine hydrochloride

Route

Oral, IV, IM

Rate of Administration

Slow bolus IV over 3–4 minutes

Infusion over 30–60 minutes

Comments

Stability in infusion depends upon diluent

OTHER INFORMATION

Sodium – 3.3 mmol/g vial of Amoxil

Do not mix with aminoglycosides

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