Alfacalcidol
CLINICAL USE
Vitamin D analogue:
DOSE IN NORMAL RENAL FUNCTION
0.25–1 microgram daily according to
responseAlternatively, up to 4 micrograms 3
times a week
PHARMACOKINETICS
400.6
Extensive plasma
protein binding
13
No data
<3/–
DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
Dose as in normal renal function
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
Not dialysed. Dose as in normal renal function
Dialysed. Dose as in normal renal
function
Dialysed. Dose as in normal renal
function
Not dialysed. Dose as in normal renal function
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
and primidone may increase metabolism
of alfacalcidol, necessitating larger doses
than normal to produce the desired effect
ADMINISTRATION
Reconstition
–
Route
O, IV
Rate of Administration
Over 30 seconds
Comments
–
OTHER INFORMATION
calcium ref range 2.1–2.6 mmol/L (total)
An IV preparation (2 micrograms/mL) and
an oral solution (2 micrograms/mL) are
also available
may need to be given immediately prior
to parathyroidectomy. Alternatively,
give 5 micrograms immediately prior to
parathyroidectomy
sesame oil