Adrenaline

CLINICAL USE


Sympathomimetic and inotropic agent

DOSE IN NORMAL RENAL FUNCTION


1–20 micrograms/minute

PHARMACOKINETICS


  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    183.2
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    50
  • %Excreted unchanged in urine &nbsp &nbsp :
    1

  • Volume of distribution (L/kg) &nbsp &nbsp &nbsp :
    No data

  • half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :
    Phase 1: 3 minutes;
    Phase 2: 10 minutes

    DOSE IN RENAL IMPAIRMENT


    GFR (mL/MIN)


  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :
    Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES


  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:
    Not dialysed. Dose as in normal renal function

  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
    Not dialysed. Dose as in normal renal function
  • HDF/high flux &nbsp :
    Unknown dialysability. Dose as in
    normal renal function
  • CAV/VVHD &nbsp &nbsp &nbsp:
    Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS


    Potentially hazardous interactions with other drugs

  • Alpha-blockers: avoid with tolazoline
  • Anaesthetics: increased risk of

    arrhythmias if given with volatile
    anaesthetics

  • Antidepressants: increased risk of

    arrhythmias and hypertension if given
    with tricyclics; MAOIs and moclobemide
    may cause hypertensive crisis.

  • Beta-blockers: increased risk of severe

    hypertension

  • Clonidine: possible increased risk of

    hypertension
    Dopaminergics: effects possibly increased

    by entacapone; avoid concomitant use
    with rasagiline

  • Sympathomimetics: effects possibly

    enhanced by dopexamine

    ADMINISTRATION


    Reconstition

  • 1 mg in 100 mL glucose 5%
  • 6 mL/hour = 1 microgram/minute –

    according to local protocol

    Route


    IV, IM, SC

    Rate of Administration


    Monitor blood pressure and adjust dose

    according to response

    Comments


    –

    OTHER INFORMATION


    Catecholamines have a high non-renal

    systemic clearance; therefore the effect of
    any renal replacement therapy is unlikely
    to be relevant

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