DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in GFR <10 mL/min
HD                     :Unlikely dialysability. Dose as in GFR <10 mL/min.
HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
CAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs
Analgesics: high dose aspirin reduces excretion (risk of toxicity)
Anti-arrhythmics: increased toxicity if hypokalaemia occursAntibacterials: effects of methenamine antagonised
Anti-epileptics: increased risk of osteomalacia with phenytoin, primidone and phenobarbital; concentration of carbamazepine increased and primidone reduced
Antihypertensives: enhanced hypotensive effect
Antipsychotics: increased risk of ventricular arrhythmias due to hypokalaemia
Atomoxetine: increased risk of ventricular arrhythmias due to hypokalaemia
Beta-blockers: increased risk of ventricular arrhythmias due to hypokalaemia with sotalol
Cardiac glycosides: increased toxicity if hypokalaemia occurs
Lithium: lithium excretion increased
ADMINISTRATION
Reconstition
Add at least 5 mL of water for injection
Route
Oral, IM, IV
Rate of Administration
Give slow IV
Comments
Avoid IM due to alkaline pH Monitor for signs of extravasation and skin necrosis during administration
OTHER INFORMATION
Use cautioned in severe renal failure
Acetazolamide sodium (Diamox) parenteral contains 2.36 millimoles of sodium per vial
Severe metabolic acidosis may occur in the elderly and in patients with reduced renal function