20 to 50     : Dose as in normal renal function
10 to 20     : Dose as in normal renal function. Use with caution
<10           : Dose as in normal renal function. Use with caution
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                        : Unlikely to be dialysed. Dose as in GFR <10 mL/min
HD                             :Unlikely to be dialysed. Dose as in GFR<<10 mL/min
HDF/high flux           :Unlikely to be dialysed. Dose as in GFR <10 mL/min
CAV/VVHD               :Unlikely to be dialysed. Dose as in GFR10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsVaccines: avoid concomitant use with live vaccines
ADMINISTRATION
Reconstition
With 10 mL of water for injection per vial
Route
IV infusion
Rate of Administration
Over 30 minutes
Comments
DO NOT SHAKE when reconstituting Add dose to 100 mL of sodium chloride 0.9%
OTHER INFORMATION
Stable for 24 hours at 2–8°C if made under aseptic conditionsAdminister with an infusion set with a low protein binding filter (pore size 0.2–1.2 μm)Manufacturer does not have any information on its use in renal impairment. Main side effects are infections and malignancies, to which renal patients may be at increased risk, therefore use with caution