iron sucrose

CLINICAL USE

Prophylaxis of iron deficiency anaemia (when oral treatment is ineffective or contraindicated) Treatment of iron deficiency during epoetin therapy especially if serum ferritin is very low (<50 nanograms/mL)

DOSE IN NORMAL RENAL FUNCTION

According to local protocol.

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :34 000–60 000

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :No data

%Excreted unchanged in urine &nbsp &nbsp : <5

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :8 litres

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :6

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Not dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsDimercaprol: avoid concomitant use Do not administer with oral iron

ADMINISTRATION

Reconstition

–

Route

IV

Rate of Administration

Bolus: 1 mL/minute Infusion: in sodium chloride 0.9% at a concentration of 1 mg/mL over 20–30 minutes per 100 mg

Comments

A test dose is required before administrationDoses can be administered via the venous limb of the dialysis machineStable for 24 hours at room temperature

OTHER INFORMATION

Some regimes are: 50–300 mg weekly —100 mg once or twice monthly —20–40 mg with each dialysis —Oral iron can be restarted 5 days after completion of the course of IV iron

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