doxapram hydrochloride

CLINICAL USE

Postoperative respiratory depression Acute respiratory failure

DOSE IN NORMAL RENAL FUNCTION

Postoperative respiratory depression: IV injection 1–1.5 mg/kg repeated at hourly intervals, or

IV infusion

2–3 mg/minute, adjusted according to response. Acute respiratory failure: 1.5–4 mg/minute as an

IV infusion

, adjusted according to response

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :433

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :No data

%Excreted unchanged in urine &nbsp &nbsp : <5

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :0.58–2.74

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :2.4–4.1/–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in normal renal function

HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

–

Route

IV bolus,

IV infusion

Rate of Administration

IV injection: over at least 30 seconds

IV infusion

as indication

Comments

Doxapram has a narrow margin of safety; the minimum effective dosage should be used and maximum recommended dosages should not be exceeded

OTHER INFORMATION

Unlike naloxone, doxapram does not reverse the other effects of opioid analgesics

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