docetaxel

CLINICAL USE


Antineoplastic agent:Treatment of breast cancer, prostate cancer and non-small cell lung cancer unresponsive to alternative therapies

DOSE IN NORMAL RENAL FUNCTION

Breast cancer: 100 mg/m 2 every 3 weeksIn combination for breast cancer, non- small cell lung cancer, prostate cancer: 75 mg/m2 every 3 weeks

PHARMACOKINETICS

  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :807.9
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :>95
  • %Excreted unchanged in urine &nbsp &nbsp : 6

  • Volume of distribution (L/kg) &nbsp &nbsp &nbsp :113 litres

  • half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :4 min(α)/36 min(β)/11.1 hr(γ)

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • HDF/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • CAV/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsAntipsychotics: avoid concomitant use with clozapine – increased risk of agranulocytosisCiclosporin: possibly inhibits metabolism of ciclosporin

    ADMINISTRATION

    Reconstition

    With diluent provided

    Route

    IV

    Rate of Administration

    Over 1 hour

    Comments

    Allow vials to come to room temperature for 5 minutesDoses of up to 200 mg can be added to 250 mL infusion bags of glucose 5% or sodium chloride 0.9%Doses greater than 200 mg should be diluted to a concentration of 0.74 mg/mLAdminister within 4 hours of dilution

    OTHER INFORMATION

    Give premedication with oral dexamethasone 16 mg daily for 3 days, starting 1 day before commencing chemotherapyCytochrome P–450 mediated metabolism. In animal studies, drug distributed to all tissues and organs except the brain. 6% and 75% of the dose is excreted via the renal and faecal route respectively within 7 days
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