20 to 50     : Dose as in normal renal function
10 to 20     : 10 mg initially and use with caution
<10           : 10 mg initially and use with caution
DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min
HD                     :Not dialysed. Dose as in GFR <10 mL/min
HDF/high flux   :Unlikely to be dialysed. Dose as in GFR <10 mL/min
CAV/VVHD      :Unlikely to be dialysed. Dose as in GFR 10 to 20 mL/min
IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAlpha-blockers: enhanced hypotensive effect – avoid concomitant useNicorandil: possibly enhanced hypotensive effect – avoid concomitant use
Nitrates: enhanced hypotensive effect– avoid concomitant use
ADMINISTRATION
Reconstition
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Route
Oral
Rate of Administration
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Comments
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OTHER INFORMATION
Maximum dosing frequency is once daily Due to lack of trial data, maximum recommended dose is 10 mg in severe renal impairment; in practice a higher dose may be used with cautionProtein binding is not affected by renal impairment.