Quinagolide.txt CLINICAL USE Hyperprolactinaemia DOSE IN NORMAL RENAL FUNCTION 75–150 micrograms daily PHARMACOKINETICS Molecular weight                           :432 (as hydrochloride) %Protein binding                           :90 %Excreted unchanged in urine     : Very little, most is excreted as metabolites in faeces and urine Volume of distribution (L/kg)       :100 litres half-life – normal/ESRD (hrs)      :17 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Use with caution Start with low dose and titrate according to response 10 to 20     : Use with caution Start with low dose and titrate according to response <10           : Use with caution Start with low dose and titrate according to response DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unknown dialysability. Dose as in GFR <10 mL/min HD                     :Unknown dialysability. Dose as in GFR <10 mL/minHDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/minCAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs None known ADMINISTRATION Reconstition– Route Oral Rate of Administration –Comments– OTHER INFORMATION Manufacturer advises to avoid use in renal impairment due to lack of dataRenally excreted metabolites (glucuronide and sulphate) are inactive. Tags: post-by-auto-php Continue Reading Previous Previous post: Propylthiouracil.txtNext Next post: SENSORINEURAL HEARING LOSS.txt Related News sotalol hydrochloride.txt tazocin.txt