Prazosin.txt

CLINICAL USE

Alpha-adrenoceptor blocker:Hypertension Congestive heart failure Raynaud’s syndrome Benign prostatic hyperplasia (BPH)

DOSE IN NORMAL RENAL FUNCTION

0.5–20 mg daily in 2–3 divided doses Raynaud’s syndrome, BPH: 0.5–2 mg twice daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :419.9

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :97

%Excreted unchanged in urine &nbsp &nbsp :

<10 &nbsp &nbsp &nbsp &nbsp &nbsp :

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :1.2–1.5

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :2–4/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Unknown dialysability. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anaesthetics: enhanced hypotensive effect

Antidepressants: enhanced hypotensive effect with MAOIs

Beta-blockers: enhanced hypotensive effect, increased risk of first dose hypotensive effect

Calcium-channel blockers: enhanced hypotensive effect, increased risk of first dose hypotensive effect

Diuretics: enhanced hypotensive effect, increased risk of first dose hypotensive effect

Moxisylyte: possibly severe postural hypotension when used in combination

Vardenafil, sildenafil and tadalafil: enhanced hypotensive effect – avoid concomitant use

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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