Pegfilgrastim.txt

CLINICAL USE

Pegylated recombinant human granulocyte-colony stimulating factor (rhG-CSF):Reduction of duration of neutropenia (except in chronic myeloid leukaemia and myelodysplastic syndromes)

DOSE IN NORMAL RENAL FUNCTION

6 mg given approximately 24 hours post chemotherapy

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :39 000

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Very high (filgrastim)

%Excreted unchanged in urine &nbsp &nbsp : Minimal

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :0.15 (filgrastim)

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :15–80/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsCytotoxics: neutropenia possibly exacerbated if administered with fluorouracil

ADMINISTRATION

Reconstition

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Route

Rate of Administration

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Comments

Incompatible with sodium chloride solutionsDiscard after 72 hours if left at room temperature

OTHER INFORMATION

Pegfilgrastim is a sustained-release form of filgrastim.

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