Meptazinol.txt

CLINICAL USE

Opioid analgesic used for moderate to severe pain

DOSE IN NORMAL RENAL FUNCTION

Oral: 200 mg every 3–6 hours IM: 75–100 mg every 2–4 hours; obstetric analgesia: 100–150 mg depending on patient’s weight (2 mg/kg)IV: 50–100 mg every 2–4 hours

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :269.8 (as hydrochloride)

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :27

%Excreted unchanged in urine &nbsp &nbsp : <5

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :3.1

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :1.4–4

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function. Start with low doses

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR <10 mL/min

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Likely dialysability. Dose as in GFR <10 mL/min

HDF/high flux &nbsp :Likely dialysability. Dose as in GFR <10 mL/min

CAV/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Antidepressants: possible CNS excitation or depression with MAOIs – avoid concomitant use; possible CNS excitation or depression with moclobemide; possibly increased sedative effects with tricyclicsSodium oxybate: enhanced effect of sodium oxybate – avoid concomitant use

ADMINISTRATION

Reconstition

–

Route

Oral, IV, IM

Rate of Administration

–

Comments

–

OTHER INFORMATION

Oral and IM peak analgesic effect occurs within 30–60 minutes and last for 3–4 hoursIV works immediately and lasts for at least 1 hour.

Tags: post-by-auto-php