Guanethidine monosulphate.txt Guanethidine monosulphate CLINICAL USE Treatment of hypertensive crisis DOSE IN NORMAL RENAL FUNCTION 10 to 20     : mg, repeated after 3 hours if required PHARMACOKINETICS Molecular weight                           :296.4 %Protein binding                           :<5 %Excreted unchanged in urine     : 25–60 Volume of distribution (L/kg)       :Large half-life – normal/ESRD (hrs)      :120–240/increased DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Give every 24 hours 10 to 20     : Give every 24 hours <10           : Give every 24–36 hours; use with caution DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/minHDF/high flux   :Likely dialysability. Dose as in GFR <10 mL/minCAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect Sympathomimetics: hypotensive effect antagonised by ephedrine, isometheptene, metaraminol, methylphenidate, noradrenaline, oxymetazoline, phenylephrine, phenylpropanolamine, pseudoephedrine and xylometazoline ADMINISTRATION Reconstition– Route IM Rate of Administration –Comments– OTHER INFORMATION Blood pressure should fall within 30 minutes of dose Tags: post-by-auto-php Continue Reading Previous Previous post: GEOGRAPHIC TONGUE.txtNext Next post: HEMORRHOIDS.txt Related News sotalol hydrochloride.txt tazocin.txt