Glimepiride.txt Glimepiride CLINICAL USE Non-insulin dependent diabetes mellitus DOSE IN NORMAL RENAL FUNCTION 1–4 mg daily; maximum 6 mg daily taken shortly before or with first main meal PHARMACOKINETICS Molecular weight                           :490.6 %Protein binding                           :>99 %Excreted unchanged in urine     : 0 (58–60% as metabolites) Volume of distribution (L/kg)       :0.113 half-life – normal/ESRD (hrs)      :5–9/Prolonged DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Start with a low dose and monitor closely DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/minHDF/high flux   :Unlikely to be dialysed. Dose as in GFR <10 mL/minCAV/VVHD      :Unlikely to be dialysed. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Analgesics: effects enhanced by NSAIDs Antibacterials: effects enhanced by chloramphenicol, sulphonamides, and trimethoprim; effect reduced by rifamycins Anticoagulants: effect possibly enhanced by coumarins; also possibly changes to INR Antifungals: concentration increased by fluconazole and miconazole and possibly voriconazoleSulfinpyrazone: enhanced effect of sulphonylureas ADMINISTRATION Reconstition– Route Oral Rate of Administration –Comments– Tags: post-by-auto-php Continue Reading Previous Previous post: GEOGRAPHIC TONGUE.txtNext Next post: HEMORRHOIDS.txt Related News sotalol hydrochloride.txt tazocin.txt