Ferrous sulphate

CLINICAL USE

Iron deficiency anaemia

DOSE IN NORMAL RENAL FUNCTION

Prophylaxis: 200 mg dailyTherapeutic: 200 mg 2–3 times dailyM/R: 1–2 tablets daily

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :278

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :–

%Excreted unchanged in urine &nbsp &nbsp : –

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :–

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Not dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Antibacterials: reduced absorption of 4-quinolones and tetracyclinesDimercaprol: avoid concomitant use Mycophenolate: may significantly reduce absorption of mycophenolate

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

One 200 mg ferrous sulphate tablet contains 65 mg elemental ironAbsorption of iron may be enhanced with concurrent administration of ascorbic acidPhosphate binding agents, e.g. calcium carbonate or magnesium carbonate, reduce absorption of iron from the gutMonitor: serum iron, transferrin saturation and ferritin levels

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