Ferrous gluconate

CLINICAL USE

Iron deficiency anaemia

DOSE IN NORMAL RENAL FUNCTION

Prophylaxis: 2 tablets dailyTherapeutic: 4–6 tablets daily in divided doses

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :482.2

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :–

%Excreted unchanged in urine &nbsp &nbsp : –

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :–

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Not dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Antibacterials: reduced absorption of 4-quinolones and tetracyclinesDimercaprol: avoid concomitant use Mycophenolate: may significantly reduce absorption of mycophenolate

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

OTHER INFORMATION

One 300 mg ferrous gluconate tablet contains 35 mg elemental ironBest taken before food to aid absorption Phosphate binding agents, e.g. calcium carbonate or magnesium carbonate, reduce absorption of iron from the gutMonitor serum iron, transferrin saturation and ferritin levels

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