Cefradine

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 250–500 mg every 6 hours (or 500 mg – 1 g every 12 hours)Severe infections: 1 g every 6 hoursInjection: 0.5–2 g every 6 hoursSurgical prophylaxis: 1–2 g at induction

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :349.4

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :8–12

%Excreted unchanged in urine &nbsp &nbsp : >90

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :0.25–0.46

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :1/6–15

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : 250–500 mg every 6 hours

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:dialysed. Dose as in GFR

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL/min

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL/min

HDF/high flux &nbsp :Dialysed. Dose as in GFR

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL/min

CAV/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced

ADMINISTRATION

Reconstition

IM: 2 mL of water for injection or sodium chloride 0.9% to each 500 mg

IV bolus: 5 mL of water for injection, sodium chloride 0.9% or glucose 5% to each 500 mg

IV infusions: 10 mL of suitable diluent to 1 g vial then add to infusion solution

Route

Oral, IM, IV

Rate of Administration

IV bolus: over 3–5 minutes

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