Cefalexin.txt Cefalexin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION 250 mg every 6 hours or 500 mg every 8–12 hours; maximum 6 g dailyRecurrent UTI prophylaxis: 125 mg at night PHARMACOKINETICS Molecular weight                           :365.4 %Protein binding                           :15 %Excreted unchanged in urine     : 80–90 Volume of distribution (L/kg)       :0.35 half-life – normal/ESRD (hrs)      :1/16 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : 500 mg every 8–12 hours <10           : 250–500 mg every 8–12 hours DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :dialysed. Dose as in GFR <10           : mL/min HD                     :Dialysed. Dose as in GFR <10           : mL/min HDF/high flux   :Dialysed. Dose as in GFR <10           : mL/min CAV/VVHD      :Dialysed. Dose as in GFR=10–20 mL/min IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugs Anticoagulants: effects of coumarins may be enhanced ADMINISTRATION Reconstition– Route Oral Rate of Administration –Comments– OTHER INFORMATION Use dose for normal renal function to treat urinary tract infection in ERF High doses, together with the use of nephrotoxic drugs such as aminoglycosides or potent diuretics, may adversely affect renal function Tags: post-by-auto-php Continue Reading Previous Previous post: CUSHINGS SYNDROME .txtNext Next post: Cinacalcet.txt Related News sotalol hydrochloride.txt tazocin.txt