Cefaclor

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

250 mg every 8 hours (dose may be doubled for more severe infections – maximum 4 g daily)

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :385.8

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :25

%Excreted unchanged in urine &nbsp &nbsp : 60–85

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :0.24–0.35

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :0.5–0.9/2.3–2.8

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function

10 to 20 &nbsp &nbsp : Dose as in normal renal function

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : 250 mg every 8 hours

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. 250 mg every 8–12 hours

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. 250–500 mg every 8 hours

HDF/high flux &nbsp :Dialysed. 250–500 mg every 8 hours

CAV/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: effects of coumarins may be enhanced

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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OTHER INFORMATION

Cefaclor associated with protracted skin reactions.

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