Capreomycin.txt Capreomycin CLINICAL USE Antibacterial agent in combination with other drugs: Tuberculosis that is resistant to first-line drugs DOSE IN NORMAL RENAL FUNCTION Deep IM injection: 1 g daily (not more than 20 mg/kg) for 2–4 months, then 1 g 2–3 times each week PHARMACOKINETICS Molecular weight                           :668.7 %Protein binding                           :No data %Excreted unchanged in urine     : 50 Volume of distribution (L/kg)       :0.37–0.42 half-life – normal/ESRD (hrs)      :2/55.5 DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : 1 g every 48 hours DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES CAPD                :Not dialysed. Dose as in GFR <10 mL/min HD                     :Dialysed. Dose as in GFR <10           : mL/min HDF/high flux   :Dialysed. Dose as in GFR <10           : mL/minCAV/VVHD      :Not dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS Potentially hazardous interactions with other drugsIncreased risk of nephrotoxicity and ototoxicity with aminoglycosides and vancomycin ADMINISTRATION ReconstitionDissolve in 2 mL of sodium chloride 0.9% or water for injection. 2–3 minutes should be allowed for complete dissolution Route Deep IM injection Rate of Administration –Comments– OTHER INFORMATION Nephrotoxic Check potassium levels as hypokalaemia may occur Desired steady state serum capreomycin level is 10 micrograms/mLDose should not exceed 1 g/day in renal failure Capreomycin sulphate 1 000 000 Units approximately equivalent to capreomycin base 1 g Tags: post-by-auto-php Continue Reading Previous Previous post: CUSHINGS SYNDROME .txtNext Next post: Cinacalcet.txt Related News sotalol hydrochloride.txt tazocin.txt