Calcium resonium

CLINICAL USE

Hyperkalaemia (not for emergency treatment)

DOSE IN NORMAL RENAL FUNCTION

Oral: 15 g 3–4 times daily in water

PR: 30 g in methylcellulose solution retained for 9 hours

PHARMACOKINETICS

Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :–

%Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :–

%Excreted unchanged in urine &nbsp &nbsp : 0

Volume of distribution (L/kg) &nbsp &nbsp &nbsp :–

half-life – normal/ESRD (hrs)&nbsp &nbsp &nbsp :–

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 &nbsp &nbsp : Dose as in normal renal function. Titrate to response

10 to 20 &nbsp &nbsp : Dose as in normal renal function. Titrate to response

<10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function. Titrate to response

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function

HDF/high flux &nbsp :Not dialysed. Dose as in normal renal function

CAV/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

None known

ADMINISTRATION

Reconstition

PR: Mix with methylcellulose solution 2% Oral: Mix with a little water, sweetened if preferred

Route

Oral or PR

Rate of Administration

–

Comments

–

OTHER INFORMATION

Ensure a regular laxative is prescribed – can mix Calcium Resonium powder with lactulose to be taken orally

Some units mix dose with a little water and give PR 4 times/day. Not retained for so long, but still effective

Calcium Resonium is not absorbed

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